The link between apoptosis and malignant cell growth is firmly established, and various forms of therapy in cancer, e.g., the use of DNA-damaging chemotherapeutic drugs, are based on the principle of inducing apoptosis in malignant cells. However, in many known instances, tumor cells develop resistance to apoptosis through various mechanisms. Thus, interventions designed to facilitate tumor cells apoptosis are likely to have a therapeutic benefit. PKCtheta, which is expressed relatively selectively in T cells, plays an important role in mature T cell activation and proliferation upon its translocation to the plasma membrane. PKCtheta is necessary for induction of the interleukin-2 (IL-2) gene because the transcription factors AP-1 and NF-kappaB, which are essential for IL-2 gene promoter activation, are main targets of PKCtheta.
Recent studies revealed that PKCtheta provides an important survival signal that protects leukemic T cells from Fas- or UV-induced apoptosis. These findings and the constitutive localization of PKCq in the membrane of some leukemic T cells suggests that it plays a role in leukemic T cell survival and/or proliferation, and that selective PKCtheta-inhibitory strategies may facilitate elimination of malignant T cells.
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Top key Players: – AbbVie Inc, Astellas Pharma Inc, Celgene Corp, CompleGen Inc, Takeda Pharmaceutical Co Ltd and Others
Protein Kinase C Theta Market by Regions,
- United States
- Southeast Asia
- South Korea
- And Others
Protein Kinase C Theta Market by Product,
Protein Kinase C Theta Market by Application,
- Ewing Sarcoma
- Insulin Resistance
- Kindney Cancer
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- A detailed overview of the Global Protein Kinase C Theta Market
- Analysis of dynamic aspects of the market such as drivers, restraints, and opportunities
- It offers insights on the latest technologies and trends
- Major Key questions addressed by various stakeholders
- To study and analyze the global market size, market shares, and profit margin
- Competitive landscape of the global market
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